VDR is a gene that codes for a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene known as the rs2228570 (FokI polymorphism), is associated with a decrease in bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and the temporal on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal locations and binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes possess an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents related to legal transactions, business or other activities that have limitations on viewing printing, downloading, or viewing. It makes use of central computers and an extranet which is a restricted access Internet connection that allows users to log on at specific times.
VDRs are typically used by investment banks and companies involved in mergers or acquisitions. They need to be able to share information in a transparent manner with potential investors or buyers. Due diligence processes may also require a huge amount of information. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.